Osteoarthritis and Degrative Joint Disease p. Lippincott Williams & Wilkins, a Wolters Kluwer Business Baltimore, MA, USA: 2012. Part 1: The disease and its risk factors. The findings of this study suggest that daily incorporation of whole blueberries may reduce pain, stiffness, and difficulty to perform daily activities, while improving gait performance, and would therefore improve quality of life in individuals with symptomatic knee OA.īlueberry gait inflammation knee osteoarthritis pain polyphenols.įelson D.T., Lawrence R.C., Dieppe P.A., Hirsch R., Helmick C.G., Jordan J.M., Kington R.S., Lane N.E., Nevitt M.C., Zhang Y., et al. However, an increasing trend for IL-13 concentration and a decreasing trend in MCP-1 concentration were noted in the blueberry group. No significant changes were observed in plasma concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, IL-13, matrix metalloproteinases (MMP)-3, MMP-13, and monocyte chemoattractant protein-1 (MCP-1) in both treatment groups. Normal walking pace single support percentage for both limbs increased ( p = or < 0.007), while double support percentage for both limbs decreased in the blueberry treatment group ( p = or < 0.003). WOMAC total score and sub-groups, including pain, stiffness, and difficulty to perform daily activities decreased significantly in the blueberry treatment group ( p < 0.05), but improvement of WOMAC total score and difficulty to perform daily activities were not observed in the placebo group. Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaires were used to assess pain and GAITRite ® electronic walkway was used to evaluate gait spatiotemporal parameters. Blood draws and assessment of pain and gait were conducted at baseline, two months, and four months. In a randomized, double-blind trial, adults age 45 to 79 with symptomatic knee OA, were randomized to either consume 40 g freeze-dried blueberry powder ( n = 33) or placebo powder ( n = 30) daily for four months. The purpose of the present study was to examine the effect of freeze dried whole blueberries on pain, gait performance, and inflammation in individuals with symptomatic knee OA. Blueberries are widely consumed and are high in dietary polyphenols, therefore regular consumption of blueberries may help improve OA. Dietary polyphenols have been studied for their anti-inflammatory properties and potential anabolic effects on the cartilage cells. Inflammation is one of the major drives of the progression of OA. The initiation and development of OA typically involves degeneration or progressive loss of the structure and function of articular cartilage. (OA) is the most common joint disorder in the world and is the most frequent cause of walking related disability among older adults in the US, which brings a significant economic burden and reduces quality of life. 9 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. 8 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. 7 School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX 76204, USA. 6 Center for Research Design and Analysis, Texas Woman's University, Houston, TX 77030, USA. 5 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. 4 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. 3 School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX 76204, USA. 2 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. 1 Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA.
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